■ Health · Exercise · Performance

Evidence-based health advice, from behind the lab bench.

Effect Size

Monstera leaves

How each issue works

Example: creatine
01 Mechanism

How it works

What actually happens inside the body, step by step, with illustrations instead of jargon.

Creatine is stored in muscle as phosphocreatine, a quick reserve for rebuilding ATP, the cell's energy currency.

02 Evidence

What the studies show

The key studies, what they tested, and how big the effect really was.

Trials of creatine with strength training, and how much extra strength they found.

03 Frontier

What's new

Open questions and newer research, clearly marked as less certain.

The brain also runs on phosphocreatine. What do studies on memory and sleep loss show?

04 Takeaway

What it means for you

Who might benefit, what was studied, and where the evidence stops.

Who the research applies to, the doses that were tested, and what's still unknown.

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Why "Effect Size"?

Does it work, and by how much?

In research, the effect size tells you how big a difference something makes, not only whether it makes one. Plenty of health claims are technically proven yet tiny in real life. That's the question I ask of every study I write about.

Study d ABCD 0.080.45 0.900.20 0 0.5 1.0
Example. A is statistically significant but tiny; D overlaps zero.